APP and Alzheimer disease: Only the tracer [11C]A-836339 has been evaluated in an AD animal model: Increased [11C]A-836339 uptake was observed in the cortex, cerebellum and whole brain of J20 mice compared to wild-type mice (Savonenko et al., 2015); another [11C]A-836339 microPET study showed that the uptake was blockable in the cortex of APP/PS1 mice (Horti et al., 2010).