In several studies of senior adults without a previous diagnosis of dementia, preoperative positive CSF Aβ, Tau, and phosphorylated Tau (P-tau) were indicated as the strongest independent predictors of POD after elective arthroplasty (Planel et al., 2007; Nakajima et al., 2015; Cunningham et al., 2019; Dutkiewicz et al., 2020). Here, MAPT is linked to dementia.