Some reports described a secondary TDP-43 pathology in parkinsonisms (7% of PD, 15.4% of CBS, 6% of PSP), although with a specific distinctive pattern of morphology, regional distribution and severity of TDP-43 aggregates compared to ALS/FTD TDP-43 proteinopathies. The gene discussed is TARDBP; the disease is proteostasis deficiencies.