TARDBP and supranuclear palsy, progressive, 1: Significantly, the possibility of a common pathogenic mechanism affecting ALS/FTD and other neurodegenerative diseases has been suggested also by the finding of TDP-43 positive aggregates in the nervous tissue of patients suffering from alpha-synucleinopathies [Parkinson’s Disease (PD), dementia with Lewy Bodies (DLB), and multiple system atrophy (MSA)], tauopathies [progressive sopranuclear palsy (PSP) and corticobasal syndrome (CBS)] Alzheimer’s disease and Huntington’s disease (Chen-Plotkin et al., 2010).