In HNSCC, SLC2A3 expression level was significantly related to B cell (r = 0.222, P = 9.96e − 07), CD8+ T cell (r = 0.229, P = 4.75e − 07), CD4+ T cell (r = 0.372, P = 3.45e − 17), macrophage (r = 0.516, P = 3.63e − 34), neutrophil (r = 0.322, P = 4.96e − 13), and dendritic cell (r = 0.49, P = 1.58e − 30). Here, CD8A is linked to head and neck squamous cell carcinoma.