Interestingly, it was found that SLC2A3 was significantly correlated to glycolysis-related gene HK2 and hypoxia-related gene HIF1A, which indicated that the expression of SLC2A3 in HNSCC was regulated via glycolysis and HIF-1 signaling pathway according to enrichment analysis. This evidence concerns the gene HIF1A and head and neck squamous cell carcinoma.