In addition, compared with the 4NQO+captisol group, MK2206 2HCl also significantly reduced MMP-9 and RhoC expression in 4NQO-induced mouse tongue cancers in the 4NQO+MK2206 2HCL group via IHC staining (Figures 12(a) and 12(b)). This evidence concerns the gene RHOC and tongue cancer.