In addition to improving viral vector delivery, the targeting of appropriate tumor genes is necessary to achieve the desired antitumor activity. Transforming growth factor β (TGF-β) is one of many targetable candidates and has pleiotropic functions regulating cell growth, differentiation, apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune response.20 The gene discussed is TGFB1; the disease is neoplasm.