TGFB1 and neoplasm: Fewer genes were affected by HSP27 downregulation than were affected by TGF-β1 downregulation,33 in all cell lines except SNU-398 cells (the most aggressive tumor cell line among the four examined), which showed very small numbers of genes with greater than 2-fold changes following TGF-β1 downregulation compared with normal cells (Figures 1B and S1).