Other authors have postulated a paradoxical increase of TNF expression in the CNS, due to the inability of TNFIs to cross the blood brain barrier (BBB), an increase in autoimmunity due to reduced TNF-mediated survival and proliferation of regulatory T cells or downregulation of interleukin-10 and upregulation of interleukin-12 and interferon-γ (20, 21). This evidence concerns the gene TNF and Autoimmunity.