The group of myelitis triggered by ICI likely includes cases with different underlying pathophysiology, which might play a role in prognosis, and we speculate that ICI-triggered paraneoplastic myelopathies (such as the case associated with CRMP-5 IgG), might have worse prognosis than ICI-triggered demyelinating myelitis. The gene discussed is DPYSL5; the disease is myelitis.