Notably, previous studies had found that alterations in serum proline-rich protein 14 (PRR14), vascular cell adhesion molecule-1(VCAM-1), and soluble CD163 (sCD163) levels, were probably linked with the constipation status (4), the severity of disease (5), the cognition levels (6), and so on in patients with PD. This evidence concerns the gene PRR14 and Parkinson disease.