NE is the major protease found within the airways of CF patients, which contributes significantly to the chronic lung damage observed in these patients (Amitani, et al., 1991; Caldwell et al., 2005; Dubois et al., 2012; Gifford and Chalmers, 2014; Voynow and Shinbash 2021). The gene discussed is ELANE; the disease is cystic fibrosis.