Huber et al., studied podoplanin expression in 120 patients with squamous cell carcinoma of the oral cavity or oropharynx and demonstrated that podoplanin is a significant predictor of lymph node metastasis (Odds Ratio: 2.70, 95% Confidence Interval: 1.11–6.54, P=0.028) (34). This evidence concerns the gene PDPN and metastatic malignant neoplasm in the lymph nodes.