Hamada et al., studied 99 patients with squamous cell carcinoma of oral cavity and demonstrated that podoplanin was a significant predictor of lymph node metastasis (Odds Ratio: 3.47, 95% Confidence Interval: 1.18‐10.2, P=0.005). Here, PDPN is linked to metastatic malignant neoplasm in the lymph nodes.