CDH5 and myocardial ischemia: As second step, we pursued studies of myocardial ischemia and reperfusion injury in mice with genetic deletion of Hif1a in different tissue compartments, including cardiomyocytes (Hif1aloxP/loxP Myosin Cre+ mice), vascular endothelial cells (Hif1aloxP/loxP VEcadherin Cre+ mice) or in myeloid inflammatory cells (Hif1aloxP/loxP LysM Cre+ mice).