Recent studies from our laboratory demonstrated the mice with deletion of myeloid-expressed netrin-1 (Ntn1loxP/loxP LysM Cre+ mice) experience increased myocardial infarct sizes and show that elevated levels of netrin-1 during myocardial infarction predominantly stems from PMNs (12). The gene discussed is NTN1; the disease is myocardial infarction.