HIF1A and myocardial infarction: In line with a functional role of myeloid-expressed Hif1a in mediating DMOG-protection we found that Hif2aloxP/loxP LysM Cre+ mice are responsive to DMOG pre-treatment with reduced ischemia and reperfusion injury compared to vehicle, as demonstrated in myocardial infarct sizes and troponin I-leakage (Figures 5A–C).