once a day) for 2 weeks could reduce the duration of ventricular arrhythmias and delay their initiation mainly through four mechanisms: (1) dose-dependent inhibition of Nav1.5 current, (2) modulating Na+-K+-ATPase activity, (3) modulating gap junctions, and (4) antioxidant properties; The former is similar to that effect exerted by class (I) AADs (7). This evidence concerns the gene SCN5A and Ventricular arrhythmia.