Ma et al. (83) found that 4-week treatment with Tongguan capsule could significantly reduce susceptibility to arrhythmias in the post-MI rat model, probably through two main underlying mechanisms: (1) increasing the expression of Cx43, (2) reducing interstitial fibrosis, hypertrophy and left ventricular remodeling. The gene discussed is GJA1; the disease is cardiac arrhythmia.