If the first studies relying on quantification of protein expression by mass-spectrometry appeared somewhat disappointing, more reliable quantitative measurements are now achievable with affinity-based methods and brought positive results such as protein expression of IL-7R in T1D (151), ADIPOQ in T2D (152), or IL-1B in CAD (150). The gene discussed is IL1B; the disease is type 2 diabetes mellitus.