If we consider candidate genes neighboring GWAS-associated lead variants, 14 are in common with the two DM pathologies (Figure 4), among which only 3 are also associated with CAD: BCAR1 (BCAR1 scaffold protein, Cas family member) whose protein product contains multiple protein-protein interaction domains and several serine and tyrosine phosphorylation sites, thus acting in different cellular pathways; CENPW (centromere protein W) acting in mitotic cell cycle; and SH2B3 (SH2B adaptor protein 3) involved in growth factor and cytokine signaling. Here, SH2B3 is linked to coronary artery disorder.