A PheWAS was conducted for T2D loss-of-function variants in the Million Veteran Program cohort and revealed 3 significant associations with metabolic and inflammatory conditions (115): ANKDD1B (Ankyrin Repeat And Death Domain Containing 1B) was notably associated with dyslipidemia, hypercholesterolemia, blood and immune cell traits, CCHCR1 (Coiled-Coil Alpha-Helical Rod Protein 1) with autoimmune traits, total cholesterol or NK cells, and LPL (Lipoprotein Lipase) with dyslipidemia or coronary atherosclerosis. The gene discussed is CCHCR1; the disease is Hypercholesterolemia.