We hypothesize that the venous and arterial thromboses observed with adenovirus-based vaccines and observed in absence of thrombocytopenia are due to the combination of at least three triggering factors, all of which may be involved in vascular inflammation and coagulation, and several arguments suggest that it is independent of anti-PF4 antibodies (T-no4TS). The gene discussed is PF4; the disease is Thrombocytopenia.