Similarly, Adachi et al. (43) reported that the heart-specific miR-499 is upregulated in the plasma of myocardial infarction patients In line with these studies, the present study also showed that DNA hypermethylation and upregulation in the gene expression of dysferlin and inflammatory cytokines were similar to the heart-specific modifications during I/R challenge. Here, DYSF is linked to myocardial infarction.