Following multivariable cox regression analyses adjusting for conventional risk factors including age, sex, BMI, hypertension, DM, hemoglobin, albumin, creatinine, LDL, HbA1c, and TMAO, elevated (tertile 3 vs. tertile 1) serum TML remained independently correlated to increased risk of the primary endpoint (HR: 1.93, 95% CI: 1.27–2.93, P = 0.002) (Table 3). The gene discussed is ALB; the disease is Hypertension.