PIEZO1 and atherosclerosis: Albarran-Juarez et al. (77) demonstrated that Piezo1 activates P2Y2 receptors and Gq/G11 protein-mediated integrins after sensing vascular perturbations, which in turn activates adhesion kinase-dependent activation of the pro-inflammatory star factor NF-κB, thereby exacerbating the development of atherosclerosis.