PIEZO1 and pulmonary arterial hypertension: In addition, it has been proposed that Piezo1 activates Ca2+-dependent signal transduction pathways such as YAP and other related transcription factors following an increase in intracellular cytoplasmic free calcium concentration, resulting in increased mechanosensitivity of the pulmonary vasculature to regulate cell proliferation and pulmonary vascular remodeling, and that aberrant mechanical stimulation of Piezo1 in PASMCs exacerbates blood flow disturbances, a process that circumferentially also promotes progression of pulmonary hypertension (53).