A total of nine hub genes were identified, including CDK1, AURKA, RRM2, CENPE, CCNB1, KIAA0101, ZWINT, TOP2A, and ASPM. Among these genes, there are four druggable genes, including AURKA, RRM2, CENPE, and TOP2A. In addition, RRM2, AURKA, and SAT1 were identified as significant ferroptosis-related genes in cSCC. This evidence concerns the gene ASPM and skin squamous cell carcinoma.