A total of nine hub genes were identified, including CDK1, AURKA, RRM2, CENPE, CCNB1, KIAA0101, ZWINT, TOP2A, and ASPM. Among these genes, there are four druggable genes, including AURKA, RRM2, CENPE, and TOP2A. In addition, RRM2, AURKA, and SAT1 were identified as significant ferroptosis-related genes in cSCC. Here, CENPE is linked to skin squamous cell carcinoma.