Alteration in various signal pathways includes modulation of mTORC2 associated signaling pathways, decreased phosphorylation of p-protein kinase C alpha (PKCα), Akt, declined expression of Rictor and F-actin known for the activation of cell growth and organization of the actin cytoskeleton indicating the involvement of mTORC2/F-actin pathway in tumor suppression induced by CA (Tan et al., 2019). This evidence concerns the gene AKT1 and cancer.