However, in neuroblastoma, mammary epithelial carcinoma, and colon cancer, curcumin remedy unexpectedly via upregulated p53 expression, triggered nuclear translocation of p53, accompanied by p21 and Bax expression induction (Allegra et al., 2017; Giordano and Tommonaro, 2019). This evidence concerns the gene TP53 and neuroblastoma.