Thus, ANXA6 interacts with several proteins like p120 GAP, Raf1 and PKCalfa, downregulating this pathway, thereby acting as a tumor suppressor in several human cancers (Pons et al., 2001; Grewal et al., 2005; Muga et al., 2009; Cornely et al., 2011; Koese et al., 2013; Wang et al., 2013). This evidence concerns the gene ANXA6 and cancer.