In pancreatic ductal adenocarcinoma (PDA), cancer-associated fibroblasts (CAF)-derived extracellular vesicles containing the complex ANXA6/LRP1/TSP1 enhanced tumor aggressiveness, and ANXA6 was crucial to promote aggressive phenotypes, invasion in vitro, and metastasis formation in vivo (Leca et al., 2016). The gene discussed is ANXA6; the disease is Patent ductus arteriosus.