ANXA2 is upregulated in several tumor subtypes but in HNSCC is usually found downregulated, and low ANXA2 levels associated with poorly differentiated tumors and metastasis in OSCC, laryngeal/pharyngeal squamous cell carcinoma (Pena-Alonso et al., 2008; Rodrigo et al., 2011b, 2014). Here, ANXA2 is linked to neoplasm.