ANXA1 and head and neck squamous cell carcinoma: On the other hand, ANXA1 is markedly down-regulated in breast cancer (Anbalagan et al., 2014; Yuan et al., 2016), prostate cancer (Kang et al., 2002), esophageal cancer (Paweletz et al., 2000), cervical cancer (Liu et al., 2011), lymphoma (Santos et al., 2009), hilar cholangiocarcinoma (Wang et al., 2010), intestinal-type sinonasal adenocarcinoma (Rodrigo et al., 2011a) and also in HNSCC (Garcia Pedrero et al., 2004).