Research performed assessing the functional role of ANXA3 in cancer has demonstrated its involvement in vital processes for tumor development and progression (Liu C. et al., 2021; Yang et al., 2021), such as sustaining proliferative signals from ERK and JNK pathways in colorectal (Xu R. et al., 2019) and hepatocellular carcinomas (Tong et al., 2015), or PI3K/Akt pathway in pancreatic cancer (Wan et al., 2020). This evidence concerns the gene ANXA3 and pancreatic neoplasm.