INS and obesity due to melanocortin 4 receptor deficiency: Disruption of insulin (McGarry, 2002) and circadian (Shostak et al., 2013a; Froy and Garaulet, 2018; Kolbe et al., 2018; Lemmer and Oster, 2018; Pilorz et al., 2018) regulation of lipolysis and food intake is associated with obesity, insulin resistance, and metabolic diseases.