In this study, we further found through KEGG pathway analysis that the cytokine–cytokine receptor interaction signaling pathway, IL-17 signaling pathway, and NF-κB signaling pathway were highly involved in the CXC chemokine-VEGFA network in COAD patients, all of which are highly related to tumor angiogenesis [36, 37]. The gene discussed is NFKB1; the disease is neoplasm.