However, CXCL12/13 expression level in patients with COAD was downregulated in (1) sex (male and female), (2) pathological stage (stage 1–4), and (3) sample type (COAD) (P < 0.05) (Figures 1(h1)–1(i3)). This evidence concerns the gene CXCL12 and colon adenocarcinoma.