v-rel reticuloendotheliosis viral oncogene homolog A (RELA) and nuclear factor-kappa light polypeptide gene enhancer in B cells 1 (NFKB1) were the critical transcription factors involved with CXCL1/2/5/8/12 and VEGFA in COAD patients (P < 0.001). Here, CXCL1 is linked to colon adenocarcinoma.