Xie et al. reported that SOX8 confers chemoresistance and stemness properties and mediates EMT in tongue squamous cell carcinoma via bounding to the promoter region of Frizzled-7 (FZD7) and inducing the FZD7-mediated activation of the Wnt/β-catenin pathway [32]. This evidence concerns the gene FZD7 and tongue squamous cell carcinoma.