CFI and age-related macular degeneration: We did observe a trend toward lower GRS in CFH or CFI rare variant carriers with early or intermediate AMD compared with noncarriers with early or intermediate AMD (mean difference, 0.64; 95% CI, –0.16 to 1.45; P = 0.21) and significantly lower GRS in CFH or CFI rare variant carriers with advanced AMD compared with noncarriers with advanced AMD (mean difference, 1.02; 95% CI, 0.47–1.57; P < 0.001; Fig 1C; Table S3, available at www.ophthalmologyscience.org, sections C-1 to C-3).