CFI and age-related macular degeneration: With this study, we showed that the identification of rare CFH and CFI variants in addition to common variants is important because in some families with AMD, the genetic risk is mainly determined by a high genetic load based on common genetic variants (Fig 2), whereas in other families with AMD, the GRS is low and a rare CFH or CFI variant segregates with the disease and contribute to AMD development (Fig 3).