Compared with the high FT3/FT4 ratio group, the low FT3/FT4 ratio group was older; had significantly higher urinary albumin-to-creatinine ratio (ACR), cardiac troponin T (cTnT), N-terminal brain natriuretic peptide precursor (NTproBNP), and percentage of total crescents in non-globally sclerotic glomeruli (%Cres); had higher prevalences of hypertension, moderate to severe renal tubulopathy, and crescentic nephritis; and had a higher proportion of patients receiving glucocorticoids and immunosuppressants. The gene discussed is CST8; the disease is hypertensive disorder.