Alarin could improve depression-like behaviors through the alarin-mediated restoration of the reduction of the phosphorylation of mTOR and its downstream substrates, eukaryotic initiation factor 4E binding protein 1 (4E-BP1) in the prefrontal cortex, hippocampus, hypothalamus, and olfactory bulb in depressive disorder. This evidence concerns the gene GALP and major depressive disorder.