explored the role of ferroptosis in the progression of DKD using in vivo and in vitro experiments, and found that ferroptosis-related protein GPX4 expression was decreased, ACSL4 expression was increased, and lipid peroxide products and iron content were also increased in mouse models of DKD (43), which was similar to the results of Li et al. The gene discussed is GPX4; the disease is diabetic kidney disease.