NFE2L2 and type 2 diabetes mellitus: Clinical trials such as phase II clinical trial (NCT02801448) with broccoli sprout extract in T2D patients (119), phase II/III clinical trial (NCT03262363) evaluating the effect of curcumin on antioxidant capacity and renal function in diabetic nephropathy (120), or phase II trial (NCT00811889) determining the effects of Nrf-2 activator bardoxolone methyl in T2D patients with chronic kidney disease (121) displayed promising results for the treatment of diabetic complications.