Those findings are further supported with data showing that targeting of redox-induced modifications of regulatory factors such as kelch-like ECH-associated protein 1 (Keap1), protein kinase C (PKC), inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ), NF-kB, CCAAT/enhancer binding protein β (C/EBPβ), p38 and extracellular signal-regulated kinase (ERK) kinases or Mn-/CuZn-SOD and CAT enzymes are potential therapeutic strategies in treatment of diabetes pathogenesis (8, 105, 114, 128). Here, IKBKB is linked to diabetes mellitus.