Compared with the model group, AST, ALT and TC in serum of mice in HRP group were remarkably decreased (P<0.01), AST and TC in serum of mice in APS group were dramatically reduced (P< 0.01), and AST, ALT and TC in HRP + APS group were significantly decreased (P<0.01). The gene discussed is GPT; the disease is autoimmune polyendocrinopathy.