When patients with OSA and co-existent essential hypertension, resistant hypertension or PA were given mineralocorticoid receptor (MR) blockade for total duration of 8 weeks to 8 months, a significant reduction in AHI, hypoxic index and oxygen desaturation index was observed along with a decrease in body weight, neck circumference and blood pressure in all three groups of patients (17, 21, 22). Here, NR3C2 is linked to Hypertension resistant to conventional therapy.