As endothelial cells fall off and the intraluminal blood lipid concentration continues to rise, the patients are prone to atherosclerosis, which may lead to artery stenosis or blockage, thus causing cardiomyocyte ischemia and a series of clinical symptoms.12 Platelet aggregation plays a key role in the process of thrombus formation.13 Activated platelets not only participate in collective hemostatic and clotting mechanisms, but also activate a variety of cytokines and nerve growth factors, such as ESM-1 and NGF. This evidence concerns the gene ESM1 and atherosclerosis.