For example, meiocytes with pathogenic mutation p.S167L in HSF2BP found in premature ovarian insufficiency (POI) patients from a family, showed a reduced number of foci formed by the recombinases RAD51/DMC1, leading to crossover defect, which provided an insight into the molecular mechanism of mutation in POI and subfertility (Felipe-Medina et al., 2020). Here, DMC1 is linked to Premature ovarian insufficiency.