IFNAR1 and Zika virus infectious disease: An in vivo ZIKV infection experiment in 1-month-old IFNAR knockout ewe lambs showed that the initial viral inoculum detected at 1 h post-infection decreased rapidly to undetectable levels within the first 5–6 days after infection with no signs of viral amplification in either WT or IFNAR2−/− lambs, (Figure 6A).