Interestingly, the key genomic alterations of acral melanomas described in a previous study (Newell et al., 2020) (such as the highest proportion of triple-WT tumors, common KIT alterations, and lower frequencies of BRAF/RAS hotspot mutations) are consistent with the characteristics of the UV-low cluster in this study. The gene discussed is BRAF; the disease is acral lentiginous melanoma.