REV1 N373S SNP was associated with an increased risk of cervical cancer, while F257S SNP is associated with a reduced risk of cervical cancer and an increased risk of lung cancer in people with heavy smoking (Sakiyama et al., 2005; He et al., 2008; Dumstorf et al., 2009; Xu et al., 2013). The gene discussed is REV1; the disease is cervical cancer.