In detail, H19 serves as the precursor of miR-675 and promotes it to directly target c-Cbl and Cbl-b mRNA so as to decrease their expression, leading to sustained activation of AKT and ERK pathways as well as enhanced cell proliferation and migration in breast cancers both in vitro and in vivo (Vennin et al., 2015). Here, H19 is linked to breast carcinoma.