Additionally, Ma et al. (2018) demonstrated that restrained expression of H19 and over-expression of miR-193a-3p enhanced the survival rate of hepatoma cell line when they were tolerant to chemotherapeutic agents [Doxorubicin, paclitaxel, vinorelbine, 5-fluorouracil (5-Fu)]. This evidence concerns the gene H19 and hepatocellular carcinoma.