Besides, MBD1 (Methyl-CpG–Binding Domain Protein 1), the partner protein of H19, can induce methylation at H3K9me3 (lysine 9 of histone H3) to differentially methylated regions (DMRs) of correlated imprinted genes like IGF2, SLC38A4 (tumor suppressor in hepatocellular carcinoma) and PEG1 (Monnier et al., 2013), (Li et al., 2021). This evidence concerns the gene IGF2 and hepatocellular carcinoma.