For example, different variants in IL23R, that interfere with IL23 signaling, have protective effects not only in BD but also for ankylosing spondylitis (AS), psoriasis, and inflammatory bowel disease (IBD) (Rueda et al., 2008; Momozawa et al., 2011; Kirino et al., 2013b; Tang et al., 2014). This evidence concerns the gene IL23R and ankylosing spondylitis.