These variants were also more significantly associated with BD in East Asian populations compared to the variants with large contribution on the first PC, some such as IL10 (rs1518111 and rs1800871), TNFAIP3 (rs9494885), API5 (rs16937370) being some of the most significant variants reported to be associated with BD (Supplementary Table S1). This evidence concerns the gene API5 and Behcet disease.