As expected, some of the SNPs reported to show the most significant association with BD, such as the ones in PSORS1C1, POU5F1, MUC21, HLA-B, IL23R, and HLA-G, had Fst estimates greater than their respective genes, supporting higher BD risk allele frequency difference and differentiation in these SNPs compared to other variants in their respective genes. The gene discussed is HLA-B; the disease is Behcet disease.