Moreover, tumor cells could secrete various molecules to attract MDSCs into TME like GM-CSF and IL-6, in turn, MDSCs induce the mutations of tumor cells and express some proteins like SA100A8/9 to avoid immune surveillance (Sinha et al., 1950a; Bresnick et al., 2015; Li et al., 2020b). The gene discussed is CSF2; the disease is neoplasm.