Germline pathogenic or likely pathogenic (P/LP) variants in the CDH1 gene, which encodes E-cadherin, lead to the Diffuse Gastric and Lobular Breast Cancer (DGLBC, formerly hereditary diffuse gastric cancer, HDGC [MIM: 137215]) syndrome with an autosomal dominant pattern of inheritance. This evidence concerns the gene CDH1 and Familial gastric cancer.