A prior study of CDH1 variant data pooled from the literature and public genetic variation databases found that 13% of CDH1 variants were associated with syndromic CLP (only DGLBC and Blepharocheilodontic syndrome) and non-syndromic CLP (Selvanathan et al., 2020). This evidence concerns the gene CDH1 and CDH1-related diffuse gastric and lobular breast cancer syndrome.