SPOCK2 and neoplasm: To further find clinical factors associated with survival, we first performed univariate logistic regression analysis which found that age (HR = 1.355, CI: 1.046–1.754, p = 0.021), primary therapy outcome (HR = 0.301, CI: 0.204–0.444, p < 0.001), tumor status (HR = 9.576, CI: 4.476–20.486, p < 0.001), tumor residual (HR = 2.313, CI: 1.486–3.599, p < 0.001), and SPOCK2 expression level (HR = 1.445, CI: 1.115–1.872, p = 0.005) were significantly associated with OS (Figure 5A, Supplementary Table S1).