It has been reported to involve in oncogenesis, which may be deregulated in gliomas (Bao et al., 2017), breast cancer (Kim et al., 2015), cervical carcinoma (Maimaitirexiati et al., 2021), lung cancer (Yang et al., 2021), etc. Studies have shown that CBX7 can participate in maintaining the growth of a variety of normal cells and immortalizing mouse fibroblasts (Jung et al., 2019), but the controversy about its role persists. Here, CBX7 is linked to lung cancer.