In the present study, we examined the levels of ALP, calcium, HB, AFP, CEA, CA-125, CA-199, CA-153, CA-724, Cyfra21-1, total PSA, and NSE in the sera of elderly patients The concentrations of ALP, AFP, CEA, CA-125, CA-199, CA-153, Cyfra21-1, and NSE were found to be extremely high in elderly patients with liver metastasis of lung cancer. This evidence concerns the gene AFP and lung cancer.