After comparing the data for tumor biomarkers in elderly patients with lung cancer liver metastasis and lung cancer non-liver metastases, we found that the levels of ALP, AFP, CEA, CA-125, CA-199, CA-153, Cyfra21-1, and NSE were extremely high compared with those measured in elderly patients lung cancer non-liver metastases. This evidence concerns the gene ENO2 and lung carcinoma.