As shown in Figure 10A, in HNSCC, BAK1 has a positive correlation with CD244, CD274, CTLA4, HLA-E, and ICOS, while having a negative correlation with LGALS9; as shown in Figure 10B, NLRP1 has a positive correlation with CD244, CD274, CTLA4, HLA-E, and ICOS, while having a negative correlation with LGALS9; as shown in Figure 10C, CHMP7 correlates positively with CD244, CTLA4, ICOS, and LGALS9, and negatively with CD274 and HLA-E; similarly, as shown in Figure 10D, RIPK1 correlates positively with CD244, CD274, CTLA4, HLA-E, ICOS, and LGALS9. Here, ICOS is linked to head and neck squamous cell carcinoma.