The 42 PAGs were incorporated into the TCGA database and four genes [BAK1 (p = 0.032, HR = 1.34 (1.03–1.76)], NLRP1 [p = 0.022, HR = 0.73 (0.56–0.95)], CHMP7 [p = 0.005, HR = 0.68 (0.52–0.89)], and CYCS [p = 0.001, HR = 1.61 (1.22–2.11)] associated with the prognosis of HNSCC patients were identified following the process of survival analysis (Figure 3A). Here, CYCS is linked to head and neck squamous cell carcinoma.