Moreover, the univariate and multivariate Cox analysis suggested that CD161 expression (HR = 0.864, p = 0.05), PR status (HR = 0.396, p = 0.006), and age (HR = 1.029, p < 0.001) were independent prognostic factors for OS in BC (Table 2 and Figure 3A). Here, PGR is linked to breast cancer.