In the GSEA analysis, NK cell-mediated cytotoxicity pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, antigen processing and presentation, cell adhesion molecules cams, cytokine-cytokine receptor interaction, primary immunodeficiency, and hematopoietic cell lineage were significantly enriched in CD161 low expression group, according to NES, NOM p values, and FDR values (Figure 4). Here, KLRB1 is linked to inborn error of immunity.