Subsequently, we detected the expression of these CRGs in tumor and normal samples and found that 6 genes, FDX1, LIAS, DLD, DLAT, PDHB and MTF1, were significantly downregulated in tumors, while 2 genes, GLS and CDKN2A, were significantly upregulated (Figure 1A). This evidence concerns the gene PDHB and neoplasm.