PTGS2 (COX-2) mainly acts on cell membranes, and its expression induced by a series of stimuli is a major compound of inflammation and HF [57, 58].Under normal physiological conditions, PTGS2 (COX-2) is almost unexpressed in the liver, but excessive expression can be induced under the stimulation of various physical and chemical factors [59]. The gene discussed is PTGS2; the disease is hydrops fetalis.