A previous study has shown that heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1) participates in the biosynthetic steps of heparan sulfate (HS) and positively contributed to acute AML progression by induction of VEGF expression, which also involves in the regulation TGF-beta-mediated EMT in NSCLC [24, 25]. The gene discussed is VEGFA; the disease is non-small cell lung carcinoma.