Protein tyrosine phosphatase of regenerating liver 3 (PRL-3), encoded by PTP4A3 gene, has been proved to promote EMT through PI3K/AKT pathway and Src-ERK1/2 pathways in a variety of tumors [31, 32], which is also a hazard factor with poor survival in AML [33]. The gene discussed is AKT1; the disease is acute myeloid leukemia.