Histopathological results showed that glioblastoma IDH wild-type (20.4%) and anaplastic astrocytoma IDH wild-type (17.7%) were lower in the NO BTRE group, diffuse astrocytoma IDH wild-type (23.4%) was higher in the TRE group, and the difference in tumor histological type between the two groups was statistically significant (P < 0.001); for details, see Table 2. This evidence concerns the gene IDH1 and glioblastoma.