In a rat stroke model, the protein levels of demethylases FTO and ALKBH5 were changed, both FTO and ALKBH5 co-regulated m6A demethylation, which played a crucial role in cerebral ischemia/reperfusion (I/R) injury (Xu K. et al., 2020). This evidence concerns the gene ALKBH5 and Cerebral ischemia.