The results obtained by Xu S. et al. (2020) demonstrated that in an in vitro ischemic stroke model, oxygen and glucose deprivation/reoxygenation (OGD/R) treatment in SH-SY5Y cells induced apoptosis as evidenced by cleavage of caspase-3-poly (ADP-ribose) polymerase (PARP) and increase of Annexin V-positive staining. This evidence concerns the gene CASP3 and ischemic stroke.