Then, using LASSO regression analysis, we constructed a 4-gene signature that included PLG, ITGAV, ITGA5, and EGF. PLG was downregulated in HCC and was a protective factor for prognosis, while ITGAV, ITGA5, and EGF were upregulated in HCC and were considered risk factors for prognosis. Here, PLG is linked to hepatocellular carcinoma.